Search results for "interaction hôte-pathogène"
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Candida albicans interaction with M cells in an in vitro model of the human intestinal Follicle Associated Epithelium (FAE)
2013
National audience; Candida albicans (C. albicans) is a microorganism belonging to the commensal flora of the intestinal, oral and vaginal mucosal surfaces in healthy humans. This commensalism results from a balance between the virulence factors of the yeast and defense mechanisms of the host. However, disturbance of this balance in a vulnerable patient may result in intense mucosal colonization that promotes invasion of epithelial cells, translocation across the intestinal epithelial barrier and, eventually hematogenous dissemination. A better understanding of the mechanisms by which C. albicans interacts with the intestinal mucosa will improve our knowledge of the physiopathology of dissem…
Enterocytes'tight junctions play a protective role in limiting invasion of Candida albicans into intestinal cells
2013
National audience; C. albicans is a commensal yeast of the mucous membranes in healthy humans that can also be responsible for disseminated candidiasis, mainly originating from the digestive tract in vulnerable patients. Deciphering the cellular and molecular mechanisms of the interaction of C. albicans with enterocytes is necessary to better understand the basis of commensalism and pathogenicity of the yeast and to improve the management of disseminated candidiasis. In intestinal epithelia, E-cadherin is constitutive of the Adherens Junctions localized just below the Tight Junctions (TJs) which ensure impermeability of the intestinal barrier. We hypothesized the absence of endocytosis of C…